09-P067 Monitoring temporal and spatial Notch1 activation during pancreas specification and development using a specific cleaved Notch1 antibody
نویسندگان
چکیده
we find that that expression of claudin 5, a component of endothelial tight junctions, is dramatically down-regulated in Tal1-deficient embryos. Consistent with a defect in tight junction formation, localization of junctional components is disorganized in the Tal1-deficient endocardium. Therefore, we propose that Tal1 transcriptional targets regulate endocardial migration and tube extension through establishment of tight junctions.
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عنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009